Synthesis, spectroscopic characterization and DNA interaction of schiff base Cu(II), Ni(II) and Zn(II) complexes

A series of Cu(II), Ni(II) and Zn(II) complexes have been synthesized with newly synthesized Schiff base derived from 1,2-di(thiophen-2-yl)ethane-1,2-dione and 1,2-diaminoethane. The structural features have been arrived from their FT-IR, H NMR, C NMR, mass, UV-vis spectroscopic studies. The binding behaviours of the synthesis complexes towards calf thymus DNA have been investigated by absorption spectra, emission spectra, viscosity measurements and circular dichroic studies. The DNA binding constants reveal that all these complexes interact with DNA via intercalating binding mode with binding constants (Kb) of 4.46 x 10 M, 3.63 x 10 M and 3.01 x 10 M and Kapp of 5.16 x 10 M, 4.23 x 10 M and 3.38 x 10 M. © 2014 Universal Research Publications. All rights reserved